I vow by the living God, who has taken away my rights, by the Almighty who has embittered my soul—

Job 27:2

As God liveth, who hath taken away my judgment, and the Almighty, who hath vexed my soul,
21st Century King James Version (KJ21)

As God lives, Who has taken away my right and denied me justice, and the Almighty, Who has vexed and embittered my life,
Amplified Bible Classic (AMPC)

Vex

• to irritate; annoy; provoke
• to torment; trouble; distress; plague; worry
• to confuse or bewilder; confound

Embitter

• to make someone feel angry and unhappy for a long time

A healthful inquiry for everyone whose soul has been vexed by God.

• Is not God just in vexing my soul?
  And do not bring sorrow to God’s Holy Spirit by the way you live. Remember, he has identified you as his own, guaranteeing that you will be saved on the day of redemption.
  Ephesians 4:30 

• What can be God's design in vexing your soul?
  For his anger lasts only a moment, but his favor lasts a lifetime! Weeping may last through the night, but joy comes with the morning.
  Psalm 30:5

• May it not that He may wean you entirely from the world?
  You adulterers! Don’t you realize that friendship with the world makes you an enemy of God? I say it again: If you want to be a friend of the world, you make yourself an enemy of God.
  James 4:4 

What then is my response?

“"As the Almighty hath vexed my soul, what had I better do?" Do? Go home, and shut your door, and have an hour alone with yourself and God. That hour alone with God may be the crisis of your whole life; do try it! "And when I am alone with God, what had I better do?" Well, first, tell Him all your grief. Then tell Him all your sin. Hide nothing from Him; lay it all, naked and bare, before Him. Then ask Him to blot it all out, once for all, for Jesus Christ's sake.” - Charles H. Spurgeon 

A Vexed Soul

Then Job spoke again.
Job 26:1

Is it always necessary to speak again?

Live my life to please the Lord, not vex and grieve Him.